Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host-pathogen interactions in the bat airway epithelium

• Main Authors: Chan, Louisa L. Y., Gamage, Akshamal M., Tan, Chee Wah, Tan, Kai Sen, Liu, Jing, Tay, Douglas Jie Wen, Foo, Randy Jee Hiang, Rénia, Laurent, Wang, De Yun, Wang, Lin-Fa
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Bat; Chiroptera
• Online Access: https://hdl.handle.net/10356/164848
• Institution: Nanyang Technological University

Bats are reservoir hosts for various zoonotic viruses with pandemdic potential in humans and livestock. In vitro systems for studying bat host-pathogen interactions are of significant interest. Here, we establish protocols to generate bat airway organoids (AOs) and airway epithelial cells differenti...