Metabolic alterations and vulnerabilities in hepatocellular carcinoma

by Tenen, Daniel G., Chai, Li, Tan, Justin L.
Published 2022

NF-?B/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia

by Gerloff, D., Grundler, R., Wurm, A.A., Brauer-Hartmann, D., Katzerke, C., Hartmann, J.-U., Madan, Vikas, Muller-Tidow, C., Duyster, J., Tenen, Daniel G., Niederwieser D., Behre G.
Published 2016

NanoVar : accurate characterization of patients' genomic structural variants using low-depth nanopore sequencing

by Tham, Cheng Yong, Tirado-Magallanes, Roberto, Goh, Yufen, Fullwood, Melissa Jane, Koh, Bryan T. H., Wang, Wilson, Ng, Chin Hin, Chng, Wee Joo, Thiery, Alexandre, Tenen, Daniel G., Benoukraf, Touati
Published 2021

Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells

by Welner, Robert S., Amabile, Giovanni, Bararia, Deepak, Czibere, Akos, Yang, Henry, Zhang, Hong, Pontes, Lorena Lobo De Figueiredo, Ye, Min, Levantini, Elena, Di Ruscio, Annalisa, Martinelli, Giovanni G., Tenen, Daniel G.
Published 2016

Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines

by Hosoi, Hiroki, Niibori-Nambu, Akiko, Nah, Giselle Sek Suan, Bahirvani, Avinash Govind, Mok, Michelle Meng Huang, Sanda, Takaomi, Kumar, Alan Prem, Tenen, Daniel G, Ito, Yoshiaki, Sonoki, Takashi, Osato, Motomi
Published 2023

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA

by Sun, Wendi, Dai, Lingyun, Yu, Han, Puspita, Brenda, Zhao, Tianyun, Li, Feng, Tan, Justin L., Lim, Yan Ting, Chen, Ming Wei, Sobota, Radoslaw M., Tenen, Daniel G., Prabhu, Nayana, Nordlund, Pär
Published 2019

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

by Tan, Shi Hao, Leong, Wei Zhong, Ngoc, Phuong Cao Thi, Tan, Tze King, Bertulfo, Fatima Carla, Lim, Mei Chee, An, Omer, Li, Zhenhua, Yeoh, Allen Eng Juh, Tenen, Daniel G., Sanda, Takaomi, Fullwood, Melissa Jane
Published 2019

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia.

by Tan, Shi Hao, Leong, Wei Zhong, Ngoc, Phuong Cao Thi, Tan, Tze King, Bertulfo, Fatima Carla, Lim, Mei Chee, An, Omer, Li, Zhenhua, Yeoh, Allen Eng Juh, Fullwood, Melissa J, Tenen, Daniel G, Sanda, Takaomi
Published 2019

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

by Zhou, Qiling, Yu, Miao, Tirado-Magallanes, Roberto, Li, Bin, Kong, Lingshi, Guo, Mingrui, Tan, Zi Hui, Lee, Sanghoon, Chai, Li, Numata, Akihiko, Benoukraf, Touati, Fullwood, Melissa Jane, Osato, Motomi, Ren, Bing, Tenen, Daniel G.
Published 2022

Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer

by Hong, HuiQi, An, Omer, Chan, Tim HM, Ng, Vanessa HE, Kwok, Hui Si, Lin, Jaymie S, Qi, Lihua, Han, Jian, Tay, Daryl JT, Tang, Sze Jing, Yang, Henry, Song, Yangyang, Molias, Fernando Bellido, Tenen, Daniel G, Chen, Leilei
Published 2019

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

by Numata, Akihiko, Kwok, Hui Si, Kawasaki, Akira, Li, Jia, Zhou, Qi-Ling, Kerry, Jon, Benoukraf, Touati, Bararia, Deepak, Li, Feng, Ballabio, Erica, Tapia, Marta, Deshpande, Aniruddha J, Welner, Robert S, Delwel, Ruud, Yang, Henry, Milne, Thomas A, Taneja, Reshma, Tenen, Daniel G
Published 2019

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions

by Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Hao Tan, Jiong, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G., Fullwood, Melissa Jane
Published 2017

Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions

by Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Tan, Jiong Hao, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G, Fullwood, Melissa J
Published 2019

Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression

by Kong, Nikki R., Bassal, Mahmoud A., Tan, Hong Kee, Kurland, Jesse, V, Yong, Kol Jia, Young, John J., Yang, Yang, Li, Fudong, Lee, Jonathan D., Liu, Yue, Wu, Chan-Shuo, Stein, Alicia, Luo, Hongbo R., Silberstein, Leslie E., Bulyk, Martha L., Tenen, Daniel G., Chai, Li
Published 2022

ZNF143 protein is an important regulator of the myeloid transcription factor C/EBP

by Gonzalez, David, Luyten, Annouck, Bartholdy, Boris, Zhou, Qiling, Kardosova, Miroslava, Ebralidze, Alex, Swanson, Kenneth D, Radomska, Hanna S, Zhang, Pu, Kobayashi, Susumu S, Welner, Robert S, Levantini, Elena, Steidl, Ulrich, Chong, Gilbert, Collombet, Samuel, Choi, Min Hee, Friedman, Alan D, Scott, Linda M, Alberich-Jorda, Meritxell, Tenen, Daniel G
Published 2023

Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth

by Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane
Published 2024

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

by Liu, Bee Hui, Jobichen, Chacko, Chia, Brian C. S., Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X. Y., Li, Jia, Poulsen, Anders, Hung, Alvin W., Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chandra Shekhar, Tan, Hong Kee, Wu, Chan-Shuo, Li, Feng, Hill, Jeffrey, Joy, Joma, Chai, Li, Sivaraman, J., Tenen, Daniel G.
Published 2020

Metabolic alterations mediated by STAT3 promotes drug persistence in CML

by Patel, Sweta B., Nemkov, Travis, Stefanoni, Davide, Benavides, Gloria A., Bassal, Mahmoud A., Crown, Brittany L., Matkins, Victoria R., Camacho, Virginia, Kuznetsova, Valeriya, Hoang, Ashley T., Tenen, Danielle E., Wolock, Samuel L., Park, Jihye, Ying, Li, Yue, Zongliang, Chen, Jake Y., Yang, Henry, Tenen, Daniel G., Ferrell, Paul Brent, Lu, Rui, Darley-Usmar, Victor, D’Alessandro, A., Bhatia, Ravi, Welner, Robert S.
Published 2022

Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis

by Guo, Mingrui, Chan, Tim Hon Man, Zhou, Qiling, An, Omer, Li, Ying, Song, Yangyang, Tan, Zi Hui, Ng, Vanessa Hui En, Peramangalam, Philomina Sona, Tan, Zhi Qing, Cao, Xinang, Iwanaga, Eisaku, Matsuoka, Masao, Ooi, Melissa G. M., Jen, Wei Ying, Koh, Liang Piu, Chan, Esther, Tan, Lip Kun, Goh, Yufen, Wang, Wilson, Koh, Bryan T. H., Chun, Chan Ming, Fullwood, Melissa Jane, Chng, Wee Joo, Osato, Motomi, Pulikkan, John Anto, Yang, Henry, Chen, Leilei, Tenen, Daniel G.
Published 2023

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

by Maroni, Giorgia, Bassal, Mahmoud A, Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A, Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castano, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E, Fox, Sam, Levy, Rachel D, Meyerovitz, Claire, Tramontozzi, Peter J, Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Basseres, Daniela S, Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M, Welner, Robert S, Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G, Ali, Azhar, Tenen, Daniel G, Levantini, Elena
Published 2022