Topography of transcriptionally active chromatin in glioblastoma

• Main Authors: Xu, Liang, Chen, Ye, Huang, Yulun, Sandanaraj, Edwin, Yu, John S., Lin, Ruby Yu-Tong, Dakle, Pushkar, Ke, Xin-Yu, Chong, Yuk Kien, Koh, Lynnette, Mayakonda, Anand, Nacro, Kassoum, Hill, Jeffrey, Huang, Mo-Li, Gery, Sigal, Lim, See Wee, Huang, Zhengyun, Xu, Ying, Chen, Jianxiang, Bai, Longchuan, Wang, Shaomeng, Wakimoto, Hiroaki, Yeo, Tseng Tsai, Ang, Beng Ti, Müschen, Markus, Tang, Carol, Tan, Tuan Zea, Koeffler, H. Phillip
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Brain; Cell Culture
• Online Access: https://hdl.handle.net/10356/151048
• Institution: Nanyang Technological University

Molecular profiling of the most aggressive brain tumor glioblastoma (GBM) on the basis of gene expression, DNA methylation, and genomic variations advances both cancer research and clinical diagnosis. The enhancer architectures and regulatory circuitries governing tumor-intrinsic transcriptional div...