The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer

• Main Authors: Yeo, Xun Hui, Sundararajan, Vignesh, Wu, Zhengwei, Phua, Cheryl Zi Jin, Ho, Yin Ying, Peh, Esther Kai Lay, Chiu, Yi-Chia, Tan, Tuan Zea, Kappei, Dennis, Ho, Ying Swan, Tan, David Shao Peng, Tam, Wai Leong, Huang, Ruby Yun-Ju
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Ovary Tumor; AXL Receptor Tyrosine Kinase
• Online Access: https://hdl.handle.net/10356/171552
• Institution: Nanyang Technological University

AXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance, making it an emerging therapeutic target. The first-in-class AXL inhibitor bemcentinib (R428/BGB324) has been granted fast track designation b...