A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging

Afterglow imaging with long-lasting luminescence after cessation of light excitation provides opportunities for ultrasensitive molecular imaging; however, the lack of biologically compatible afterglow agents has impeded exploitation in clinical settings. This study presents a generic approach to tra...

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Main Authors: Jiang, Yuyan, Huang, Jiaguo, Zhen, Xu, Zeng, Ziling, Li, Jingchao, Xie, Chen, Miao, Qingqing, Chen, Jie, Chen, Peng, Pu, Kanyi
其他作者: School of Chemical and Biomedical Engineering
格式: Article
語言:English
出版: 2019
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在線閱讀:https://hdl.handle.net/10356/86574
http://hdl.handle.net/10220/49860
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機構: Nanyang Technological University
語言: English
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總結:Afterglow imaging with long-lasting luminescence after cessation of light excitation provides opportunities for ultrasensitive molecular imaging; however, the lack of biologically compatible afterglow agents has impeded exploitation in clinical settings. This study presents a generic approach to transforming ordinary optical agents (including fluorescent polymers, dyes, and inorganic semiconductors) into afterglow luminescent nanoparticles (ALNPs). This approach integrates a cascade photoreaction into a single-particle entity, enabling ALNPs to chemically store photoenergy and spontaneously decay it in an energy-relay process. Not only can the afterglow profiles of ALNPs be finetuned to afford emission from visible to near-infrared (NIR) region, but also their intensities can be predicted by a mathematical model. The representative NIR ALNPs permit rapid detection of tumors in living mice with a signal-to-background ratio that is more than three orders of magnitude higher than that of NIR fluorescence. The biodegradability of the ALNPs further heightens their potential for ultrasensitive in vivo imaging.