Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin

• Main Authors: Peng, Minhua, Watanabe, Satoru, Chan, Kitti Wing Ki, He, Qiuyan, Zhao, Ya, Zhang, Zhongde, Lai, Xiaoping, Luo, Dahai, Vasudevan, Subhash G., Li, Geng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Luteolin; Dengue Virus
• Online Access: https://hdl.handle.net/10356/86618; http://hdl.handle.net/10220/44137
• Institution: Nanyang Technological University

In many countries afflicted with dengue fever, traditional medicines are widely used as panaceas for illness, and here we describe the systematic evaluation of a widely known natural product, luteolin, originating from the “heat clearing” class of herbs. We show that luteolin inhibits the replicatio...