Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513

• Main Authors: Wong, Yee Hwa, Kumar, Akshita, Liew, Chong Wai, Tharakaraman, Kannan, Srinivasaraghavan, Kannan, Sasisekharan, Ram, Verma, Chandra, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Dengue Virus; Humanized Monoclonal Antibody 513
• Online Access: https://hdl.handle.net/10356/86830; http://hdl.handle.net/10220/45324
• Institution: Nanyang Technological University

Dengue is a widespread viral disease with 3.6 billion people at risk worldwide. Humanized monoclonal antibody (mAb) 513, currently undergoing clinical trials in Singapore, targets an epitope on the envelope protein domain III exposed at the surface of the viral particle. This antibody potently neutr...