Enhanced Delta-Notch lateral inhibition model incorporating intracellular notch heterogeneity and tension-dependent rate of Delta-Notch binding that reproduces sprouting angiogenesis patterns

• Main Authors: Koon, Yen Ling, Zhang, Songjing, Koh, Cheng Gee, Chiam, Keng-Hwee, Muhammad Bakhait Rahmat
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Delta-Notch Lateral Inhibition Model; Intracellular Notch Heterogeneity
• Online Access: https://hdl.handle.net/10356/86832; http://hdl.handle.net/10220/45275
• Institution: Nanyang Technological University

Endothelial cells adopt unique cell fates during sprouting angiogenesis, differentiating into tip or stalk cells. The fate selection process is directed by Delta-Notch lateral inhibition pathway. Classical Delta-Notch models produce a spatial pattern of tip cells separated by a single stalk cell, or...