LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains

• Main Authors: Ou, Sirong, Tan, Mei-Hua, Weng, Ting, Li, HoiYeung, Koh, Cheng-Gee
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: LIM Kinase; Centrosome Integrity
• Online Access: https://hdl.handle.net/10356/86849; http://hdl.handle.net/10220/45334
• Institution: Nanyang Technological University

Abnormal centrosome number and function have been implicated in tumour development. LIM kinase1 (LIMK1), a regulator of actin cytoskeleton dynamics, is found to localize at the mitotic centrosome. However, its role at the centrosome is not fully explored. Here, we report that LIMK1 depletion resulte...