Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes
Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distens...
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sg-ntu-dr.10356-868612020-11-01T05:13:07Z Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes Goh, S. Bing, Sun Seneviratna, A. Phua, C. T. Dalan, Rinkoo Lee Kong Chian School of Medicine (LKCMedicine) Diabetes Endothelial Function Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distensibility of a distal vessel should be a good biomarker for subclinical disease. We have developed a device capable of measuring reactive hyperaemia induced changes in the radial artery flow, volumetric changes and accompanying effects on the vessel wall. The measurement is based on the magnetic flux disturbance upon haemodynamic modulation as blood flows through a uniformly applied magnetic field, and generates what we have termed the radial artery maximum distensibility index (RA-MDI). In a proof-of-concept study we found significant correlations between RA-MDI and cardiovascular risk factors, scoring systems and carotid artery intima-media thickness. Further large scale prospective studies need to be conducted to ascertain the correlations with cardiovascular events. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2018-07-27T07:48:45Z 2019-12-06T16:30:25Z 2018-07-27T07:48:45Z 2019-12-06T16:30:25Z 2018 Journal Article Dalan, R., Goh, S., Bing, S., Seneviratna, A., & Phua, C. T. (2018). Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes. Scientific Reports, 8(1), 8649-. 2045-2322 https://hdl.handle.net/10356/86861 http://hdl.handle.net/10220/45325 10.1038/s41598-018-26931-2 en Scientific Reports © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 11 p. application/pdf |
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Diabetes Endothelial Function Goh, S. Bing, Sun Seneviratna, A. Phua, C. T. Dalan, Rinkoo Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
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Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distensibility of a distal vessel should be a good biomarker for subclinical disease. We have developed a device capable of measuring reactive hyperaemia induced changes in the radial artery flow, volumetric changes and accompanying effects on the vessel wall. The measurement is based on the magnetic flux disturbance upon haemodynamic modulation as blood flows through a uniformly applied magnetic field, and generates what we have termed the radial artery maximum distensibility index (RA-MDI). In a proof-of-concept study we found significant correlations between RA-MDI and cardiovascular risk factors, scoring systems and carotid artery intima-media thickness. Further large scale prospective studies need to be conducted to ascertain the correlations with cardiovascular events. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Goh, S. Bing, Sun Seneviratna, A. Phua, C. T. Dalan, Rinkoo |
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Article |
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Goh, S. Bing, Sun Seneviratna, A. Phua, C. T. Dalan, Rinkoo |
author_sort |
Goh, S. |
title |
Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
title_short |
Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
title_full |
Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
title_fullStr |
Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
title_full_unstemmed |
Proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
title_sort |
proof-of-concept study for an enhanced surrogate marker of endothelial function in diabetes |
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2018 |
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https://hdl.handle.net/10356/86861 http://hdl.handle.net/10220/45325 |
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1683493174544171008 |