Allosteric cross-talk in chromatin can mediate drug-drug synergy

• Main Authors: Adhireksan, Zenita, Palermo, Giulia, Riedel, Tina, Ma, Zhujun, Muhammad, Reyhan, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curtis Alexander
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Drug; Chromatin
• Online Access: https://hdl.handle.net/10356/87027; http://hdl.handle.net/10220/44277
• Institution: Nanyang Technological University

Exploitation of drug–drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug–drug synergy mediated by allosteric cross-talk in chromatin, wher...