Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila

• Main Authors: Teo, Ryan Yee Wei, Anand, Amit, Sridhar, Vishweshwaren, Okamura, Katsutomo, Kai, Toshie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Heterochromatin Protein 1a; Drosophila
• Online Access: https://hdl.handle.net/10356/87041; http://hdl.handle.net/10220/45294
• Institution: Nanyang Technological University

In metazoan germline, Piwi-interacting RNAs (piRNAs) provide defence against transposons. Piwi–piRNA complex mediates transcriptional silencing of transposons in nucleus. Heterochromatin protein 1a (HP1a) has been proposed to function downstream of Piwi-piRNA complex in Drosophila. Here we show that...