Heterochromatin protein 1a functions for piRNA biogenesis predominantly from pericentric and telomeric regions in Drosophila

• المؤلفون الرئيسيون: Teo, Ryan Yee Wei, Anand, Amit, Sridhar, Vishweshwaren, Okamura, Katsutomo, Kai, Toshie
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Heterochromatin Protein 1a; Drosophila
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87041; http://hdl.handle.net/10220/45294
• المؤسسة: Nanyang Technological University

In metazoan germline, Piwi-interacting RNAs (piRNAs) provide defence against transposons. Piwi–piRNA complex mediates transcriptional silencing of transposons in nucleus. Heterochromatin protein 1a (HP1a) has been proposed to function downstream of Piwi-piRNA complex in Drosophila. Here we show that...