Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

• Main Authors: Ge, Xin, Wang, Xianghong, Bo, En, Luo, Yuemei, Chen, Si, Liu, Xinyu, Wang, Nanshuo, Chen, Shufen, Chen, Shi, Li, Jinhan, Liu, Linbo
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Medical Optics Instrumentation; Optical Coherence Tomography
• Online Access: https://hdl.handle.net/10356/87062; http://hdl.handle.net/10220/44253
• Institution: Nanyang Technological University

In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture radar (SAR). Using numerical simulations and imaging experiments, we verified that this technique can maintain a diffraction-limited transverse resolution along a DOF that is ∼10∼10 times larger than the confocal parameter. The ability to extend the DOF without signal loss and sidelobe artifacts may ultimately overcome the DOF limitation in high-resolution OCT.