Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans

• Main Authors: Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Human; Mouse
• Online Access: https://hdl.handle.net/10356/87240; http://hdl.handle.net/10220/44345
• Institution: Nanyang Technological University

Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. Despite a resurgent interest in these modifications, the biochemistry o...