High-intensity focused ultrasound ablation around the tubing

High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, l...

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Main Authors: Siu, Jun Yang, Liu, Chenhui, Zhou, Yufeng
Other Authors: Tu, Juan
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/87251
http://hdl.handle.net/10220/44334
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-872512023-03-04T17:12:04Z High-intensity focused ultrasound ablation around the tubing Siu, Jun Yang Liu, Chenhui Zhou, Yufeng Tu, Juan School of Mechanical and Aerospace Engineering High Intensity Focused Ultrasound Acoustic Radiation Force Impulse Imaging High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters of 0.76 mm and 3 mm) at varied flow speeds (17–339 cm/s) by HIFU ablation was photographically recorded. Produced lesions have decreased length (~30%) but slightly increased width (~6%) in comparison to that without the embedded tubing. Meanwhile, bubble activities during the exposures were measured by passive cavitation detection (PCD) at the varied pulse repetition frequency (PRF, 10–30 Hz) and duty cycle (DC, 10%-20%) of the HIFU bursts. High DC and low flow speed were found to produce stronger bubble cavitation whereas no significant influence of the PRF. In addition, high-speed photography illustrated that the rupture of tubing was produced consistently after the first HIFU burst within 20 ms and then multiple bubbles would penetrate into the intraluminal space of tubing through the rupture site by the acoustic radiation force. Alignment of HIFU focus to the anterior surface, middle, and posterior surface of tubing led to different characteristics of vessel rupture and bubble introduction. In summary, HIFU-induced vessel rupture is possible as shown in this phantom study; produced lesion sizes and shapes are dependent on the focus alignment to the tubing, flow speed, and tubing properties; and bubble cavitation and the formation liquid jet may be one of the major mechanisms of tubing rupture as shown in the high-speed photography. Published version 2018-01-24T03:10:22Z 2019-12-06T16:38:11Z 2018-01-24T03:10:22Z 2019-12-06T16:38:11Z 2017 Journal Article Siu, J. Y., Liu, C., & Zhou, Y. (2017). High-intensity focused ultrasound ablation around the tubing. PLOS ONE, 12(11), e0188206-. https://hdl.handle.net/10356/87251 http://hdl.handle.net/10220/44334 10.1371/journal.pone.0188206 en PLOS ONE © 2017 Siu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 18 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic High Intensity Focused Ultrasound
Acoustic Radiation Force Impulse Imaging
spellingShingle High Intensity Focused Ultrasound
Acoustic Radiation Force Impulse Imaging
Siu, Jun Yang
Liu, Chenhui
Zhou, Yufeng
High-intensity focused ultrasound ablation around the tubing
description High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters of 0.76 mm and 3 mm) at varied flow speeds (17–339 cm/s) by HIFU ablation was photographically recorded. Produced lesions have decreased length (~30%) but slightly increased width (~6%) in comparison to that without the embedded tubing. Meanwhile, bubble activities during the exposures were measured by passive cavitation detection (PCD) at the varied pulse repetition frequency (PRF, 10–30 Hz) and duty cycle (DC, 10%-20%) of the HIFU bursts. High DC and low flow speed were found to produce stronger bubble cavitation whereas no significant influence of the PRF. In addition, high-speed photography illustrated that the rupture of tubing was produced consistently after the first HIFU burst within 20 ms and then multiple bubbles would penetrate into the intraluminal space of tubing through the rupture site by the acoustic radiation force. Alignment of HIFU focus to the anterior surface, middle, and posterior surface of tubing led to different characteristics of vessel rupture and bubble introduction. In summary, HIFU-induced vessel rupture is possible as shown in this phantom study; produced lesion sizes and shapes are dependent on the focus alignment to the tubing, flow speed, and tubing properties; and bubble cavitation and the formation liquid jet may be one of the major mechanisms of tubing rupture as shown in the high-speed photography.
author2 Tu, Juan
author_facet Tu, Juan
Siu, Jun Yang
Liu, Chenhui
Zhou, Yufeng
format Article
author Siu, Jun Yang
Liu, Chenhui
Zhou, Yufeng
author_sort Siu, Jun Yang
title High-intensity focused ultrasound ablation around the tubing
title_short High-intensity focused ultrasound ablation around the tubing
title_full High-intensity focused ultrasound ablation around the tubing
title_fullStr High-intensity focused ultrasound ablation around the tubing
title_full_unstemmed High-intensity focused ultrasound ablation around the tubing
title_sort high-intensity focused ultrasound ablation around the tubing
publishDate 2018
url https://hdl.handle.net/10356/87251
http://hdl.handle.net/10220/44334
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