Protecting microRNAs from RNase degradation with steric DNA nanostructures

• Main Authors: Qian, H., Tay, Chor Yong, Setyawati, M. I., Chia, S. L., Lee, D. S., Leong, D. T.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: DNA; Nanostructures
• Online Access: https://hdl.handle.net/10356/87261; http://hdl.handle.net/10220/44373
• Institution: Nanyang Technological University

Tumor suppressive microRNAs are potent molecules that might cure cancer, one day. Despite the many advanced strategies for delivery of these microRNAs to the cell, there are few therapeutic microRNAs in clinical use. Progress in microRNA bioapplications is hindered by a high vulnerability of exogene...