Biological and mechanical interplay at the macro- and microscales modulates the cell-niche fate

• Main Authors: Sarig, Udi, Sarig, Hadar, Gora, Aleksander, Krishnamoorthi, Muthu Kumar, Au-Yeung, Gigi Chi Ting, de-Berardinis, Elio, Chaw, Su Yin, Mhaisalkar, Priyadarshini, Bogireddi, Hanumakumar, Ramakrishna, Seeram, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Machluf, Marcelle
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Human Umbilical Vein Endothelial Cells (HUVECs); Cell-niche Interactions
• Online Access: https://hdl.handle.net/10356/87363; http://hdl.handle.net/10220/45398
• Institution: Nanyang Technological University

Tissue development, regeneration, or de-novo tissue engineering in-vitro, are based on reciprocal cell-niche interactions. Early tissue formation mechanisms, however, remain largely unknown given complex in-vivo multifactoriality, and limited tools to effectively characterize and correlate specific...