Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

• Main Authors: Thion, Morgane Sonia, Low, Donovan, Silvin, Aymeric, Chen, Jinmiao, Grisel, Pauline, Schulte-Schrepping, Jonas, Blecher, Ronnie, Ulas, Thomas, Squarzoni, Paola, Hoeffel, Guillaume, Coulpier, Fanny, Siopi, Eleni, David, Friederike Sophie, Scholz, Claus, Foo, Shihui, Lum, Josephine, Amoyo, Arlaine Anne, Larbi, Anis, Poidinger, Michael, Buttgereit, Anne, Lledo, Pierre-Marie, Greter, Melanie, Chan, Jerry Kok Yen, Amit, Ido, Beyer, Marc, Schultze, Joachim Ludwig, Schlitzer, Andreas, Pettersson, Sven, Ginhoux, Florent, Garel, Sonia
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: CXCR4; Antibiotics
• Online Access: https://hdl.handle.net/10356/87431; http://hdl.handle.net/10220/44422
• Institution: Nanyang Technological University

Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that m...