Dihydrofolate-reductase mutations in Plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia

• Main Authors: Yeo, Tsin Wen, Auburn, Sarah, Anstey, Nicholas M., Grigg, Matthew J., Barber, Bridget E., Marfurt, Jutta, Imwong, Mallika, William, Timothy, Bird, Elspeth, Piera, Kim A., Aziz, Ammar, Boonyuen, Usa, Drakeley, Christopher J., Cox, Jonathan, White, Nicholas J., Cheng, Qin
• Other Authors: Tsuboi, Takafumi
• Format: Article
• Language: English
• Published: 2018
• Subjects: Malaria; DRNTU::Science::Medicine; Plasmodium Knowlesi
• Online Access: https://hdl.handle.net/10356/87597; http://hdl.handle.net/10220/46773
• Institution: Nanyang Technological University

Background: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxin...