Nicotinamide metabolism modulates the proliferation/differentiation balance and senescence of human primary keratinocytes

• Main Authors: Tan, Chye Ling, Chin, Toby, Tan, Christina Yan Ru, Rovito, Holly A., Quek, Ling Shih, Oblong, John E., Bellanger, Sophie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: HPK (Human Primary Keratinocyte); ATP (Adenosine Triphosphate); Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/87642; http://hdl.handle.net/10220/49890
• Institution: Nanyang Technological University

Nicotinamide (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for DNA repair, glycolysis, and oxidative phosphorylation. NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3-dimensional organotypic skin m...