Structural basis for linezolid binding site rearrangement in the Staphylococcus aureus ribosome

• Main Authors: Tofayel Ahmed, Belousoff, Matthew J., Eyal, Zohar, Radjainia, Mazdak, Bamert, Rebecca S., Matzov, Donna, Bashan, Anat, Zimmerman, Ella, Mishra, Satabdi, Cameron, David, Elmlund, Hans, Peleg, Anton Y., Bhushan, Shashi, Lithgow, Trevor, Yonath, Ada
• Other Authors: Zhang, Gongyi
• Format: Article
• Language: English
• Published: 2019
• Subjects: Staphylococcus; Antibiotic Resistance; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/87660; http://hdl.handle.net/10220/50196
• Institution: Nanyang Technological University

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural information demonstrated that a single amino acid deletion in riboso...