Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids
Polymeric particulate delivery systems are vastly explored for the delivery of chemotherapeutic agents. However, the preparation of polymeric particulate systems with the capability of providing sustained release of two or more drugs is still a challenge. Herein, poly (D,L-lactic-co-glycolic acid, 5...
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sg-ntu-dr.10356-877322023-07-14T15:52:02Z Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids Baek, Jong-Suep Choo, Chee Chong Tan, Nguan Soon Loo, Joachim Say Chye School of Materials Science & Engineering School of Biological Sciences Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences Engineering Microparticles Controlled-release Polymeric particulate delivery systems are vastly explored for the delivery of chemotherapeutic agents. However, the preparation of polymeric particulate systems with the capability of providing sustained release of two or more drugs is still a challenge. Herein, poly (D,L-lactic-co-glycolic acid, 50:50) hollow microparticles co-loaded with doxorubicin and paclitaxel were developed through double-emulsion solvent evaporation technique. Hollow microparticles were formed through the addition of an osmolyte into the fabrication process. The benefits of hollow over solid microparticles were found to be higher encapsulation efficiency and a more rapid drug release rate. Further modification of the hollow microparticles was accomplished through the introduction of methyl-β-cyclodextrin. With this, a higher encapsulation efficiency of both drugs and an enhanced cumulative release were achieved. Spheroid study further demonstrated that the controlled release of the drugs from the methyl-β-cyclodextrin -loaded hollow microparticles exhibited enhanced tumor regressions of MCF-7 tumor spheroids. Such hollow dual-drug-loaded hollow microparticles with sustained releasing capabilities may have a potential for future applications in cancer therapy. MOE (Min. of Education, S’pore) Published version 2018-08-08T05:35:44Z 2019-12-06T16:48:15Z 2018-08-08T05:35:44Z 2019-12-06T16:48:15Z 2017 Journal Article Baek, J.-S., Choo, C. C., Tan, N. S., & Loo, S. C. J. (2017). Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids. Oncotarget, 8(46), 80841-80852. https://hdl.handle.net/10356/87732 http://hdl.handle.net/10220/45549 10.18632/oncotarget.20591 en Oncotarget © 2017 Baek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. application/pdf |
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Microparticles Controlled-release Baek, Jong-Suep Choo, Chee Chong Tan, Nguan Soon Loo, Joachim Say Chye Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
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Polymeric particulate delivery systems are vastly explored for the delivery of chemotherapeutic agents. However, the preparation of polymeric particulate systems with the capability of providing sustained release of two or more drugs is still a challenge. Herein, poly (D,L-lactic-co-glycolic acid, 50:50) hollow microparticles co-loaded with doxorubicin and paclitaxel were developed through double-emulsion solvent evaporation technique. Hollow microparticles were formed through the addition of an osmolyte into the fabrication process. The benefits of hollow over solid microparticles were found to be higher encapsulation efficiency and a more rapid drug release rate. Further modification of the hollow microparticles was accomplished through the introduction of methyl-β-cyclodextrin. With this, a higher encapsulation efficiency of both drugs and an enhanced cumulative release were achieved. Spheroid study further demonstrated that the controlled release of the drugs from the methyl-β-cyclodextrin -loaded hollow microparticles exhibited enhanced tumor regressions of MCF-7 tumor spheroids. Such hollow dual-drug-loaded hollow microparticles with sustained releasing capabilities may have a potential for future applications in cancer therapy. |
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School of Materials Science & Engineering |
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School of Materials Science & Engineering Baek, Jong-Suep Choo, Chee Chong Tan, Nguan Soon Loo, Joachim Say Chye |
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Article |
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Baek, Jong-Suep Choo, Chee Chong Tan, Nguan Soon Loo, Joachim Say Chye |
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Baek, Jong-Suep |
title |
Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
title_short |
Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
title_full |
Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
title_fullStr |
Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
title_full_unstemmed |
Sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
title_sort |
sustained-releasing hollow microparticles with dual-anticancer drugs elicit greater shrinkage of tumor spheroids |
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2018 |
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https://hdl.handle.net/10356/87732 http://hdl.handle.net/10220/45549 |
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1772825315991617536 |