Germline mutations in cancer predisposition genes are frequent in sporadic sarcomas

• Main Authors: Chan, Sock Hoai, Lim, Weng Khong, Nur Diana Binte Ishak, Li, Shao-Tzu, Goh, Wei Lin, Tan, Gek San, Lim, Kiat Hon, Teo, Melissa, Ng, Cedric Chuan Young, Malik, Simeen, Tan, Mann Hong, Teh, Jonathan Yi Hui, Chin, Francis Kuok Choon, Kesavan, Sittampalam, Selvarajan, Sathiyamoorthy, Tan, Patrick, Teh, Bin Tean, Soo, Khee Chee, Mohamad Farid, Quek, Richard, Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Medicine; Germline Mutations; Sarcoma
• Online Access: https://hdl.handle.net/10356/87842; http://hdl.handle.net/10220/46812
• Institution: Nanyang Technological University

Associations of sarcoma with inherited cancer syndromes implicate genetic predisposition in sarcoma development. However, due to the apparently sporadic nature of sarcomas, little attention has been paid to the role genetic susceptibility in sporadic sarcoma. To address this, we performed targeted-g...