Improving acetyl-CoA biosynthesis in Saccharomyces cerevisiae via the overexpression of pantothenate kinase and PDH bypass

• Main Authors: Liu, Wenshan, Zhang, Bo, Jiang, Rongrong
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Pantothenate Kinase; DRNTU::Engineering::Bioengineering; Acetyl-CoA
• Online Access: https://hdl.handle.net/10356/87852; http://hdl.handle.net/10220/46887
• Institution: Nanyang Technological University

Background: Acetyl-CoA is an important precursor in Saccharomyces cerevisiae. Various approaches have been adopted to improve its cytosolic level previously with the emphasis on engineering the “acetyl-” part of acetyl-CoA. To the best of our knowledge, there have been no reports on engineering the...