Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13–RhoA–ROCK signaling pathway

• Main Authors: Mu, Ganggang, Ding, Qianshan, Li, Hongyan, Zhang, Li, Zhang, Lingli, He, Ke, Wu, Lu, Deng, Yunchao, Yang, Dongmei, Wu, Lianlian, Xu, Ming, Zhou, Jie, Yu, Honggang
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Pancreatic Cancer Cell; Gastrin; DRNTU::Engineering::Electrical and electronic engineering; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/87891; http://hdl.handle.net/10220/45566
• Institution: Nanyang Technological University

The mechanism by which gastrin promotes pancreatic cancer cell metastasis is unclear. The process of directing polarized cancer cells toward the extracellular matrix is principally required for invasion and distant metastasis; however, whether gastrin can induce this process and its underlying mecha...