Identification of antibacterial components in human hair shafts

Identification of antibacterial components in human hair shafts

Antimicrobial peptides (AMPs) are evolutionarily old components of innate immunity. AMPs identified in human skin include defensins, cathelicidin, dermcidin, psoriasin, and RNase7 (1, 2). Some AMPs, such as the human cathelicidin peptide LL-37, are upregulated during inflammation in skin (1). Variou...

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Bibliographic Details
Main Authors: Subbaiah, Roopa S., Kerk, Swat Kim, Lian, Yilong, Lunny, Declan, Sze, Siu Kwan, Ng, Kee Woei, Schmidtchen, Artur, Adav, Sunil Shankar
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2018
Subjects:
DRNTU::Science::Biological sciences
Antimicrobial Peptides (AMPs)
Human Hair Shafts
Online Access:https://hdl.handle.net/10356/87924
http://hdl.handle.net/10220/45603
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Institution: Nanyang Technological University
Language: English
Description
Summary:Antimicrobial peptides (AMPs) are evolutionarily old components of innate immunity. AMPs identified in human skin include defensins, cathelicidin, dermcidin, psoriasin, and RNase7 (1, 2). Some AMPs, such as the human cathelicidin peptide LL-37, are upregulated during inflammation in skin (1). Various microbes colonize the hair follicular canal, and various AMPs may modulate their population and composition (3, 4). It is not known whether the hair shaft per se contains functionally active antimicrobials.

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