Structure and Interactions of A Host Defense Antimicrobial Peptide Thanatin in Lipopolysaccharide Micelles Reveal Mechanism of Bacterial Cell Agglutination

• Main Authors: Sinha, Sheetal, Zheng, Liangzhen, Mu, Yuguang, Ng, Wun Jern, Bhattacharjya, Surajit
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Thanatin; Bacterial Cell Agglutination
• Online Access: https://hdl.handle.net/10356/87993; http://hdl.handle.net/10220/44511
• Institution: Nanyang Technological University

Host defense cationic Antimicrobial Peptides (AMPs) can kill microorganisms including bacteria, viruses and fungi using various modes of action. The negatively charged bacterial membranes serve as a key target for many AMPs. Bacterial cell death by membrane permeabilization has been well perceived....