Comparative transcriptomics unravels prodigiosin's potential cancer-specific activity between human small airway epithelial cells and lung adenocarcinoma cells

• Main Authors: Davient, Bala, Ng, Jessica Pei Zhen, Xiao, Qiang, Li, Liang, Yang, Liang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Prodigiosin; Small Molecule; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/87996; http://hdl.handle.net/10220/47030
• Institution: Nanyang Technological University

Objective: Non-Small Cell Lung Cancer (NSCLC) is extremely lethal upon metastasis and requires safe and effective systemic therapies to improve a patient's prognosis. Prodigiosin (PG) appears to selectively and effectively target cancer but not healthy cells. However, PG's cancer-specific...