In-depth characterization of congenital Zika syndrome in immunocompetent mice : antibody-dependent enhancement and an antiviral peptide therapy

• Main Authors: Camargos, Vidyleison N., Foureaux, Giselle, Medeiros, Daniel C., da Silveira, Vivian T., Queiroz-Junior, Celso M., Matosinhos, Ana Luisa B., Moreira, Thaiane P., Queiroz, Victória F., Dias, Ana Carolina F., Passos, Ingredy, Silva, Ludmila C., Wnuk, Natália T., Macari, Soraia, Silva, Tarcília, Garlet, Gustavo P., Jackman, Joshua A., Soriani, Frederico M., Ribeiro, Fabíola M., Teixeira, Antônio L., Cho, Nam-Joon, Teixeira, Mauro M., Costa, Vivian V., Souza, Danielle G., Figueiredo, André F. A., Sousa, Carla D. F., Santana, Karina T. O., Real, Ana Luíza C. V., Mourão, Flávio A. G., Oliveira, Milton A. P., Moraes, Márcio F. D., Mendes, Eduardo M. A. M., Costa, Guilherme M. J., Oliveira, Antônio C. P.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Congenital Zika Virus Infection; Congenital Zika Syndrome; Engineering::Materials
• Online Access: https://hdl.handle.net/10356/88024; http://hdl.handle.net/10220/49309
• Institution: Nanyang Technological University

Background: Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZI...