Mechanistic action of weak acid drugs on biofilms

• Main Authors: Kundukad, Binu, Schussman, Megan, Yang, Kaiyuan, Seviour, Thomas, Yang, Liang, Rice, Scott A., Kjelleberg, Staffan, Doyle, Patrick S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Biofilm; Weak Acid Drug; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88068; http://hdl.handle.net/10220/45622
• Institution: Nanyang Technological University

Selective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication of biofilms formed by the mucoid strain of Pseudomonas aeruginosa and investigat...