Characterisation of cross-linked hydrogel structures for cartilage applications
Alginate is a biocompatible natural hydrogel being explored to create cartilage replacements either on its own or as part of a composite material. Bioprinting technologies based on photopolymerization principles are being used make such structures. In this paper, the effect of functionalization t...
محفوظ في:
المؤلفون الرئيسيون: | , , |
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مؤلفون آخرون: | |
التنسيق: | Conference or Workshop Item |
اللغة: | English |
منشور في: |
2018
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الموضوعات: | |
الوصول للمادة أونلاين: | https://hdl.handle.net/10356/88220 http://hdl.handle.net/10220/45750 |
الوسوم: |
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المؤسسة: | Nanyang Technological University |
اللغة: | English |
الملخص: | Alginate is a biocompatible natural hydrogel being explored to create cartilage
replacements either on its own or as part of a composite material. Bioprinting technologies based
on photopolymerization principles are being used make such structures. In this paper, the effect of
functionalization time on the mechanical morphology, swelling and degradation characterization
of cross-linked alginate hydrogel is investigated. Alginate, chemically-modified with methacrylate
groups and different reaction times is considered, by dissolving functionalized alginate with 1.5%
photoinitiator solution and crosslinked by ultraviolet (UV) light (8 mW/cm2). Results show that by
increasing the functionalization time, it was possible to obtain alginate material with a high level
of unsaturation resulting in a less porous structure with high mechanical properties and a reduction
of swelling. The influence of increasing the prepolymer concentration, reaction time and the
amount of photoinitiator (PI) on mechanical and biomimetic properties of resulting hydrogels led
to increased mechanical stiffness when measured at 10% strain. The swelling ratio of
Photocrosslinked alginate hydrogels was studied and initial findings link this behavior to
functionalization reaction time. |
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