Skin dendritic cell and T cell activation associated with dengue shock syndrome

• Main Authors: Duyen, Huynh Thi Le, Cerny, Daniela, Trung, Dinh The, Pang, Jassia, Velumani, Sumathy, Toh, Ying Xiu, Qui, Phan Tu, Hao, Nguyen Van, Simmons, Cameron, Haniffa, Muzlifah, Wills, Bridget, Fink, Katja
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Skin; Dengue Shock Syndrome; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88278; http://hdl.handle.net/10220/45672
• Institution: Nanyang Technological University

The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular...