AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

• Main Authors: Wong, Chui Fann, Shin, Joon, Manimekalai, Malathy Sony Subramanian, Saw, Wuan Geok, Yin, Zhan, Bhushan, Shashi, Kumar, Arvind, Ragunathan, Priya, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Thioredoxin and Peroxiredoxin System; AhpC
• Online Access: https://hdl.handle.net/10356/88317; http://hdl.handle.net/10220/44598
• Institution: Nanyang Technological University

Despite the highly oxidative environment of the phagosomal lumen, the need for maintaining redox homeostasis is a critical aspect of mycobacterial biology. The pathogens are equipped with the sophisticated thioredoxin- (Trx) and peroxiredoxin system, including TrxC and the alkyl hydroperoxide reduct...