Genetic signatures of HIV-1 envelope-mediated bystander apoptosis

• Main Authors: Joshi, Anjali, Lee, Raphael T. C., Mohl, Jonathan, Sedano, Melina, Khong, Wei Xin, Ng, Oon Tek, Maurer-Stroh, Sebastian, Garg, Himanshu
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: AIDS; Apoptosis; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88404; http://hdl.handle.net/10220/45805
• Institution: Nanyang Technological University

The envelope (Env) glycoprotein of HIV is an important determinant of viral pathogenesis. Several lines of evidence support the role of HIV-1 Env in inducing bystander apoptosis that may be a contributing factor in CD4+ T cell loss. However, most of the studies testing this phenomenon have been cond...