Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering

• Main Authors: Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Lösche, Mathias, Linstedt, Adam D.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Materials; Golgi; Fluorescence
• Online Access: https://hdl.handle.net/10356/88421; http://hdl.handle.net/10220/45879
• Institution: Nanyang Technological University

The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the plane of th...