Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer

• Main Authors: Di Sante, Gabriele, Di Rocco, Agnese, Pupo, Claudia, Casimiro, Mathew C., Pestell, Richard G.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cyclin D1; DNA Damage
• Online Access: https://hdl.handle.net/10356/88473; http://hdl.handle.net/10220/44624
• Institution: Nanyang Technological University

Cell cycle control proteins govern events that leads to the production of two identical daughter cells. Distinct sequential temporal phases, Gap 1 (G1), Gap 0 (G0), Synthesis (S), Gap 2 (G2) and Mitosis (M) are negotiated through a series of check points during which the favorability of the local ce...