Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: A study of formulation optimization, toxicity, and pharmacokinetics

Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: A study of formulation optimization, toxicity, and pharmacokinetics

The Poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (mPEG-PLGA) nanoparticles carrying acetyltanshinone IIA (ATA), a novel anti-breast cancer agent, were prepared by ultrasonic emulsion method to enhance the bioavailability and reduce the toxicity. Systematic optimization of en...

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Bibliographic Details
Main Authors: Wang, Qi, Wei, Na, Liu, Xiaofeng, Luo, Kathy Qian
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2018
Online Access:https://hdl.handle.net/10356/88491
http://hdl.handle.net/10220/44625
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/88491
http://hdl.handle.net/10220/44625

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