Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression

• Main Authors: Schepens, Jan TG, Kasri, Nael Nadif, Augustine, George James, Hendriks, Wiljan JAJ, Erkens, Mirthe, Tanaka-Yamamoto, Keiko, Cheron, Guy, Márquez-Ruiz, Javier, Prigogine, Cynthia
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cerebellum; Long-term Synaptic Plasticity; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/88520; http://hdl.handle.net/10220/45847
• Institution: Nanyang Technological University

Background: Regulation of synaptic connectivity, including long-term depression (LTD), allows proper tuning of cellular signalling processes within brain circuitry. In the cerebellum, a key centre for motor coordination, a positive feedback loop that includes mitogen-activated protein kinases (MAPKs...