mcr-3 and mcr-4 Variants in Carbapenemase-Producing Clinical Enterobacteriaceae Do Not Confer Phenotypic Polymyxin Resistance

• Main Authors: Teo, Jeanette W. P., Kalisvar, Marimuthu, Venkatachalam, Indumathi, Ng, Oon Tek, Lin, Raymond T. P., Octavia, Sophie
• Other Authors: Ledeboer, Nathan A.
• Format: Article
• Language: English
• Published: 2018
• Subjects: Bioinformatics; Enterobacteriaceae
• Online Access: https://hdl.handle.net/10356/88578; http://hdl.handle.net/10220/44670
• Institution: Nanyang Technological University

The worldwide distribution of plasmid-mediated colistin resistance determinants (mcr-1, mcr-2, mcr-3, and mcr-4) coupled to the emerging observation that colistin resistance is more prevalent in carbapenem-resistant Enterobacteriaceae (CRE) (1, 2) presents a daunting challenge in combatting antimicr...