Tissue-resident CD169 + macrophages form a crucial front line against plasmodium infection

• Main Authors: Gupta, Pravesh, Lai, Si Min, Sheng, Jianpeng, Tetlak, Piotr, Balachander, Akhila, Claser, Carla, Renia, Laurent, Karjalainen, Klaus, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Macrophages; Plasmodium Berghei Infection; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88661; http://hdl.handle.net/10220/46948
• Institution: Nanyang Technological University

Tissue macrophages exhibit diverse functions, ranging from the maintenance of tissue homeostasis, including clearance of senescent erythrocytes and cell debris, to modulation of inflammation and immunity. Their contribution to the control of blood-stage malaria remains unclear. Here, we show that in...