Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo
The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial effi...
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Main Authors: | Parmar, Anish, Lakshminarayanan, Rajamani, Iyer, Abhishek, Mayandi, Venkatesh, Goh, Eunice Tze Leng, Lloyd, Daniel G., Chalasani, Madhavi Latha Somaraju, Verma, Navin Kumar, Prior, Stephen H., Beuerman, Roger W., Madder, Annemieke, Taylor, Edward J., Singh, Ishwar |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2018
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/88754 http://hdl.handle.net/10220/44693 |
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Institution: | Nanyang Technological University |
Language: | English |
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