Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

• Main Authors: Parmar, Anish, Lakshminarayanan, Rajamani, Iyer, Abhishek, Mayandi, Venkatesh, Goh, Eunice Tze Leng, Lloyd, Daniel G., Chalasani, Madhavi Latha Somaraju, Verma, Navin Kumar, Prior, Stephen H., Beuerman, Roger W., Madder, Annemieke, Taylor, Edward J., Singh, Ishwar
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Bacterial Infection; Teixobactin
• 在線閱讀: https://hdl.handle.net/10356/88754; http://hdl.handle.net/10220/44693
• 機構: Nanyang Technological University

The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial effi...