Protein–protein interactions modulate the docking-dependent E3-ubiquitin ligase activity of Carboxy-terminus of Hsc70-interacting protein (CHIP)

CHIP is a tetratricopeptide repeat (TPR) domain protein that functions as an E3-ubiquitin ligase. As well as linking the molecular chaperones to the ubiquitin proteasome system, CHIP also has a docking-dependent mode where it ubiquitinates native substrates, thereby regulating their steady state lev...

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Bibliographic Details
Main Authors: Narayan, Vikram, Landré, Vivien, Ning, Jia, Hernychova, Lenka, Muller, Petr, Verma, Chandra, Walkinshaw, Malcolm D., Blackburn, Elizabeth A., Ball, Kathryn L.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
Online Access:https://hdl.handle.net/10356/88869
http://hdl.handle.net/10220/46059
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Institution: Nanyang Technological University
Language: English
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