ANRIL promoter DNA methylation : a perinatal marker for later adiposity

• Main Authors: Lillycrop, Karen, Murray, Robert, Cheong, Clara, Teh, Ai Ling, Clarke-Harris, Rebecca, Barton, Sheila, Costello, Paula, Garratt, Emma, Cook, Eloise, Titcombe, Philip, Shunmuganathan, Bhuvaneshwari, Liew, Samantha J., Chua, Yong-Cai, Lin, Xinyi, Wu, Yonghui, Burdge, Graham C., Cooper, Cyrus, Inskip, Hazel M., Karnani, Neerja, Hopkins, James C., Childs, Caroline E., Chavez, Carolina Paras, Calder, Philip C., Yap, Fabian, Lee, Yung Seng, Chong, Yap Seng, Melton, Philip E., Beilin, Lawrie, Huang, Rae-Chi, Gluckman, Peter D., Harvey, Nick, Hanson, Mark A., Holbrook, Joanna D., Godfrey, Keith M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Adiposity; DNA Methylation; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/88871; http://hdl.handle.net/10220/45974
• Institution: Nanyang Technological University

Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identified a novel association between the level of...