Engineering nanoparticle synthesis using microbial factories

Biologically engineered entities have enabled discoveries in the past decade and a half, spanning from novel routes for the syntheses of drugs and value-added products to carbon capture. The precise cellular re-programming has extended to the production of nanomaterials owing to their ever-growing d...

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Main Authors: Pasula, Rupali Reddy, Lim, Sierin
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/88893
http://hdl.handle.net/10220/44784
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-888932023-12-29T06:46:21Z Engineering nanoparticle synthesis using microbial factories Pasula, Rupali Reddy Lim, Sierin School of Chemical and Biomedical Engineering NTU-Northwestern Institute for Nanomedicine Nanoparticle Synthesis Microbial Reaction Vessels Biologically engineered entities have enabled discoveries in the past decade and a half, spanning from novel routes for the syntheses of drugs and value-added products to carbon capture. The precise cellular re-programming has extended to the production of nanomaterials owing to their ever-growing demand. The primary advantage of the biological nanoparticle synthesis is the eco-friendly approach performed at ambient temperature and pressure, where the usage of harsh chemical stabilisers and capping agents is eliminated, providing ease of handling and downstream processing. Although the techniques hold great promise, many short comings hamper their scalability; thus, rendering them unsuitable for industrial applications. A fundamental understanding of the underlying mechanisms which involve various enzymes of different metabolic pathways is most crucial in surmounting these impending blocks leading to successfully engineered systems which can be tuned in accordance with the goals of specific applications. This mini review highlights the recent developments in nanoparticle synthesis that employ the use of microbial reaction vessels with specific emphasis on engineering of these biological entities such as bacteria, yeast, fungi and algae. Also presented are the challenges and future trends in this domain where novel and engineered approaches will be the most consequential. Published version 2018-05-14T09:22:23Z 2019-12-06T17:13:13Z 2018-05-14T09:22:23Z 2019-12-06T17:13:13Z 2017 2017 Journal Article Pasula, R. R., & Lim, S. (2017). Engineering nanoparticle synthesis using microbial factories. Engineering Biology, 1(1), 12-17. https://hdl.handle.net/10356/88893 http://hdl.handle.net/10220/44784 10.1049/enb.2017.0009 207299 en Engineering Biology © 2017 The author(s). This is an open access article published by the IET under the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/3.0/). 6 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Nanoparticle Synthesis
Microbial Reaction Vessels
spellingShingle Nanoparticle Synthesis
Microbial Reaction Vessels
Pasula, Rupali Reddy
Lim, Sierin
Engineering nanoparticle synthesis using microbial factories
description Biologically engineered entities have enabled discoveries in the past decade and a half, spanning from novel routes for the syntheses of drugs and value-added products to carbon capture. The precise cellular re-programming has extended to the production of nanomaterials owing to their ever-growing demand. The primary advantage of the biological nanoparticle synthesis is the eco-friendly approach performed at ambient temperature and pressure, where the usage of harsh chemical stabilisers and capping agents is eliminated, providing ease of handling and downstream processing. Although the techniques hold great promise, many short comings hamper their scalability; thus, rendering them unsuitable for industrial applications. A fundamental understanding of the underlying mechanisms which involve various enzymes of different metabolic pathways is most crucial in surmounting these impending blocks leading to successfully engineered systems which can be tuned in accordance with the goals of specific applications. This mini review highlights the recent developments in nanoparticle synthesis that employ the use of microbial reaction vessels with specific emphasis on engineering of these biological entities such as bacteria, yeast, fungi and algae. Also presented are the challenges and future trends in this domain where novel and engineered approaches will be the most consequential.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Pasula, Rupali Reddy
Lim, Sierin
format Article
author Pasula, Rupali Reddy
Lim, Sierin
author_sort Pasula, Rupali Reddy
title Engineering nanoparticle synthesis using microbial factories
title_short Engineering nanoparticle synthesis using microbial factories
title_full Engineering nanoparticle synthesis using microbial factories
title_fullStr Engineering nanoparticle synthesis using microbial factories
title_full_unstemmed Engineering nanoparticle synthesis using microbial factories
title_sort engineering nanoparticle synthesis using microbial factories
publishDate 2018
url https://hdl.handle.net/10356/88893
http://hdl.handle.net/10220/44784
_version_ 1787136496431529984