Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia

• المؤلفون الرئيسيون: Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Medicine; Stem Cell; Molecular Mechanisms
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88907; http://hdl.handle.net/10220/46988
• المؤسسة: Nanyang Technological University

Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differentiated MODY5 human-induced pluripotent stem cell...