Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia

Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia

Patients with an HNF1BS148L/+ mutation (MODY5) typically exhibit pancreatic hypoplasia. However, the molecular mechanisms are unknown due to inaccessibility of patient material and because mouse models do not fully recapitulate MODY5. Here, we differentiated MODY5 human-induced pluripotent stem cell...

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Bibliographic Details
Main Authors: Teo, Adrian Kee Keong, Lau, Hwee Hui, Valdez, Ivan Achel, Dirice, Ercument, Tjora, Erling, Raeder, Helge, Kulkarni, Rohit N.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
DRNTU::Science::Medicine
Stem Cell
Molecular Mechanisms
Online Access:https://hdl.handle.net/10356/88907
http://hdl.handle.net/10220/46988
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/88907
http://hdl.handle.net/10220/46988

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