CD28 null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death

• Main Authors: Pera, Alejandra, Caserta, Stefano, Albanese, Fabio, Blowers, Pinar, Morrow, George, Terrazzini, Nadia, Smith, Helen Elizabeth, Rajkumar, Chakravarthi, Reus, Bernhard, Msonda, James R, Verboom, Murielle, Hallensleben, Michael, Blasczyk, Rainer, Davies, Kevin A, Kern, Florian
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: CD28 null CD8 T-cells; DRNTU::Science::Medicine; CD28 null CD4 T-cells
• Online Access: https://hdl.handle.net/10356/88932; http://hdl.handle.net/10220/46068
• Institution: Nanyang Technological University

An increased risk of cardiovascular death in Cytomegalovirus (CMV)-infected individuals remains unexplained, although it might partly result from the fact that CMV infection is closely associated with the accumulation of CD28null T-cells, in particular CD28null CD4 T-cells. These cells can directly...