Targeted phenotypic screening in plasmodium falciparum and toxoplasma gondii reveals novel modes of action of medicines for malaria venture malaria box molecules

• Main Authors: Preiser, Peter Rainer, Reddy, D. Srinivasa, Tan, Kevin S. W., Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh, Subramanian, Gowtham, Belekar, Meenakshi A., Shukla, Anurag, Tong, Jie Xin, Sinha, Ameya, Chu, Trang T. T., Kulkarni, Akshay S.
• Other Authors: Sullivan, William J.
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Malaria; MMV Malaria Box
• Online Access: https://hdl.handle.net/10356/88939; http://hdl.handle.net/10220/48346
• Institution: Nanyang Technological University

The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens against Plasmodium falciparum and Toxoplasma gondii, we report phenotype-...