Metronidazole causes skeletal muscle atrophy and modulates muscle chronometabolism

• Main Authors: Manickam, Ravikumar, Oh, Hui Yun Penny, Tan, Chek Kun, Paramalingam, Eeswari, Wahli, Walter
• 其他作者: Interdisciplinary Graduate School (IGS)
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Metronidazole; Gut Dysbiosis; DRNTU::Science::Medicine
• 在線閱讀: https://hdl.handle.net/10356/88966; http://hdl.handle.net/10220/46017
• 機構: Nanyang Technological University

Antibiotics lead to increased susceptibility to colonization by pathogenic organisms, with different effects on the host-microbiota relationship. Here, we show that metronidazole treatment of specific pathogen-free (SPF) mice results in a significant increase of the bacterial phylum Proteobacteria i...